Noah Webster's New International Dictionary of the English Language

1. (n.) A hard protuberance; a hard swelling or rising; a bunch; a lump; as, a knob in the flesh, or on a bone.

2. (n.) A knoblike ornament or handle; as, the knob of a lock, door, or drawer.

3. (n.) A rounded hill or mountain; as, the Pilot Knob.

4. (n.) See Knop.

5. (v. i.) To grow into knobs or bunches; to become knobbed.